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Melatonin as a Brain Support Molecule for Alzheimer's Disease

Melatonin as a Brain Support Molecule for Alzheimer's Disease

Oct 31 Sean Orr, M.D.

Unlocking the Potential of Melatonin in Combating Alzheimer’s Disease

Alzheimer’s disease (AD) is a relentless neurodegenerative disorder marked by memory loss, cognitive decline, and the buildup of harmful proteins in the brain. While there’s no cure yet, recent research highlights melatonin—a hormone best known for regulating sleep—as a promising ally in the fight against AD.

Why Melatonin?

Melatonin isn’t just a sleep aid. It boasts powerful antioxidant and anti-inflammatory properties that protect brain cells from damage. By scavenging harmful free radicals and reducing inflammation, melatonin helps maintain a healthier brain environment.

Battling Amyloid-Beta and Tau Proteins

Two proteins, amyloid-beta (Aβ) and tau, play central roles in AD. Melatonin helps keep these proteins in check. It lowers the production of Aβ by influencing key enzymes involved in its creation and boosts the brain’s ability to clear away existing Aβ plaques. Additionally, melatonin directly interacts with tau proteins, preventing them from clumping into tangles that disrupt brain function.

Protecting the Powerhouses of Cells

Mitochondria, the energy producers in our cells, often malfunction in AD, leading to increased oxidative stress and cell death. Melatonin enhances a process called mitophagy, which removes damaged mitochondria, ensuring that neurons remain energized and healthy.

 

"The synthetic pathway and metabolism of melatonin and possible sites for some nutrients to influence on the synthesis. Enzymes are in underlined capital letters in italics. TRP, tryptophan; TPH, tryptophan hydroxylase; TDO, tryptophan dioxygenase; AADC, aromatic aminoacid decarboxylase; AANAT, arylalkylamone-N-acetyltransferase; HIOMT, hydroxyindole-O-methyltransferase; 6-SMT, 6-sulphatoxymelatonin; SAMe, S-adenosylmethionine." (After Peuhkuri, et. al.)

 

Clinical Benefits and Safety

Clinical studies show that melatonin supplementation can improve cognitive function and sleep quality in individuals with AD and mild cognitive impairment (MCI). Its safety profile is impressive, with minimal side effects even at higher doses, making it a safe addition to AD management strategies.

Looking Ahead

While melatonin shows great promise, more research is needed to fully understand its impact on AD pathology and to determine the optimal dosing strategies. Combining melatonin with other therapeutic agents could potentially enhance its protective effects, offering hope for more effective AD treatments in the future.

In Conclusion

Melatonin emerges as a multifaceted neuroprotective agent, addressing key aspects of Alzheimer’s disease from reducing harmful protein buildup to protecting cellular energy centers. Melatonin can become a valuable component in the arsenal against AD, offering a beacon of hope for millions affected by this challenging condition.

 

How to Incorporate Melatonin into Your Routine

Dietary Supplements of melatonin are formulated with synergy in mind, and they are designed for ease of use. 

  • Capsules: Convenient for standardized dosing.
  • Gummies: Easy for consumption and tasty.
  • Sleep Strips: Convenient packaging and easy absorption in the mouth.

The supplement 5-HTP contains the amino acid, Tryptophan, which is then converted to melatonin through metabolic processes.

  

Dosage and Safety

  • Recommended Dosage: Melatonin 1-3 mg nightly seems to be the most effective dose for most people.
  • 5-HTP is best taken in the morning, so that its effect is maximal before bed.
  • Safety Profile: Generally considered safe with minimal side effects. However, very high doses (greater than 9 mg) can backfire and increase wakefulness.
  • Consult a Healthcare Professional: Before starting any new supplement, especially if you have underlying health conditions or are taking medications.

 

How Action Potential Supplements Can Support You

  • At Action Potential Supplements, we are dedicated to harnessing the power of natural ingredients to support brain health.
  • Quality Assurance: Sourced from reputable growers and tested for purity and potency.

 

 

 

References

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